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| Section | Weight | Objectives |
|---|---|---|
| Clinical Study Operations | 15% | - Project management
|
| Professionalism and Ethical Practice | 15% | - Professional standards
|
| Data Management and Informatics | 17% | - Data collection
|
| Study Design and Conduct | 17% | - Study implementation
|
| Regulatory and Compliance Requirements | 17% | - ICH Guidelines
|
| Ethical and Participant Safety Considerations | 19% | - Ethical principles
|
1. A new device trial is being considered. Before committing to participate in the trial, what is the MOST important item the PI needs to evaluate?
A) Information to be included in the advertising flyer
B) Availability of qualified staff to conduct the trial
C) Location of stored trial records
D) Length of time to receive the approved trial device
2. A PI is being considered for an industry-sponsored study. The PI sees approximately 20 patients per month who meet the study criteria. The PI does not have access to a Positron Emission Tomography (PET) scanner, which is required for the protocol. The PI is already taking part in three other studies. Should the Sponsor choose this PI?
A) No, the PI is taking part in too many ongoing studies to participate in this study.
B) Yes, the PI can perform other imaging scans instead of the PET scans.
C) No, the PI does not have the resources to perform all protocol-required procedures.
D) Yes, the PI has a sufficient patient population to take part in this study.
3. The site submitted all start-up documents for a study to the sponsor and the IRB/IEC. The site also has subjects identified for screening. What should happen FIRST?
A) Verify subject eligibility
B) Schedule a site initiation visit
C) Ship/receive IP
D) Obtain IRB/IEC approval
4. The CRC is prepared to consent a cognitively impaired participant to an Alzheimer's clinical trial. The CRC is required to utilize which of the following in the consent process?
A) A legally acceptable representative
B) A family member
C) A witness
D) A member of the research team
5. A protocol requires participants to take IP for 6 months. The protocol allows for any participants who are noncompliant to be replaced by enrolling additional participants, except if it is due to an AE. The investigator has enrolled 12 participants.
The status of the enrolled participants is as follows:
* 3 participants were withdrawn due to noncompliance
* 1 participant withdrew consent after experiencing severe nausea
* 1 participant had to discontinue IP for an unscheduled hospitalization
* 1 participant who is not returning for visits
* 2 participants completed the 6 months of treatment
* 4 participants currently on IP
How many participants should be replaced?
A) 5 participants
B) 4 participants
C) 6 participants
D) 3 participants
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: C | Question # 3 Answer: D | Question # 4 Answer: A | Question # 5 Answer: D |
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